The Regin Smoke-Bottle is used to check negative air pressure in hospital patient rooms and for asbestos abatement. Each Smoke-Bottle contains an ampule with titaniumtetrachloride that when broken inside the plastic bottle, emits dense real smoke when squeezed. Each bottle can be used during 24 hours after the ampule has been broken. No open flame or sparks are required to activate the Smoke-Bottle. The smoke generated by the Smoke-Bottle is corrosive.